DNA methylation dynamics in health and disease

Nat Struct Mol Biol. 2013 Mar;20(3):274-81. doi: 10.1038/nsmb.2518.


DNA methylation is an epigenetic mark that is erased in the early embryo and then re-established at the time of implantation. In this Review, dynamics of DNA methylation during normal development in vivo are discussed, starting from fertilization through embryogenesis and postnatal growth, as well as abnormal methylation changes that occur in cancer.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CpG Islands
  • DNA Methylation*
  • Embryo Implantation
  • Embryonic Development / genetics
  • Epigenesis, Genetic
  • Gene Expression Regulation, Developmental*
  • Humans
  • Neoplasms / genetics*