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Comparative Study
. 2013 May;18(5):608-14.
doi: 10.1111/tmi.12089. Epub 2013 Mar 7.

Bayesian Modelling to Estimate the Test Characteristics of Coprology, Coproantigen ELISA and a Novel Real-Time PCR for the Diagnosis of Taeniasis

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Comparative Study

Bayesian Modelling to Estimate the Test Characteristics of Coprology, Coproantigen ELISA and a Novel Real-Time PCR for the Diagnosis of Taeniasis

Nicolas Praet et al. Trop Med Int Health. .
Free article

Abstract

Objective: To estimate and compare the performances of coprology, copro-Ag ELISA and real-time polymerase chain reaction assay (copro-PCR) for detection of Taenia solium tapeworm carriers.

Methods: The three diagnostic tests were applied on 817 stool samples collected in two Zambian communities where taeniasis is endemic. A Bayesian approach was used to allow estimation of the test characteristics. Two (0.2%; 95% Confidence Interval (CI): 0-0.8), 67 (8.2%; 95% CI: 6.4-10.3) and 10 (1.2%; 95% CI: 0.5-2.2) samples were positive using coprology, copro-Ag ELISA and copro-PCR, respectively.

Results: Specificities of 99.9%, 92.0% and 99.0% were determined for coprology, copro-Ag ELISA and copro-PCR, respectively. Sensitivities of 52.5%, 84.5% and 82.7% were determined for coprology, copro-Ag ELISA and copro-PCR, respectively.

Conclusions: We urge for additional studies exploring possible cross-reactions of the copro-Ag ELISA and for the use of more sensitive tests, such as copro-PCR, for the detection of tapeworm carriers, which is a key factor in controlling the parasite in endemic areas.

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