The antifungal activity of graphene oxide-silver nanocomposites

Biomaterials. 2013 May;34(15):3882-90. doi: 10.1016/j.biomaterials.2013.02.001. Epub 2013 Mar 7.


Graphene oxide (GO)-based nanocomposites' antibacteria activity exhibits great potential in clinical application. Herein we reported for the first time the preparation and enhanced antifungal activity of carbon nanoscrolls (CNSs) filled with silver nanoparticles (AgNPs). The nanoscrolls filled with silver nanoparticles were prepared by sonication, TEM picture showed AgNPs filled and wrapped inside prepared nanocomposites, the antifungal test showed that CNSs-AgNPs exhibited ideal lengthened activities against Candida albicans and Candida tropical compared with the GO-AgNPs nanocomposites based on silver nanoparticles directly deposited on the surface of grapheme oxides, which is caused by CNS-AgNPs' controlled durative slow-releasing of silver ion. It is also observed that graphene oxides exhibited no antifungal activity. In conclusion, the carbon nanoscrolls composed of graphene oxides and silver nanoparticles own enhanced and lengthened antifungal activity, and have great potential in applications such as clinical nosocomial infections and local antifungal therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Candida / cytology
  • Candida / drug effects
  • Candida / ultrastructure
  • Carbon / chemistry
  • Graphite / chemistry*
  • Microbial Sensitivity Tests
  • Microbial Viability / drug effects
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Silver / pharmacology*
  • Spectrophotometry, Ultraviolet
  • X-Ray Diffraction


  • Antifungal Agents
  • Silver
  • Carbon
  • Graphite