Genome organization and long-range regulation of gene expression by enhancers

Curr Opin Cell Biol. 2013 Jun;25(3):387-94. doi: 10.1016/ Epub 2013 Mar 4.


It is now well accepted that cell-type specific gene regulation is under the purview of enhancers. Great strides have been made recently to characterize and identify enhancers both genetically and epigenetically for multiple cell types and species, but efforts have just begun to link enhancers to their target promoters. Mapping these interactions and understanding how the 3D landscape of the genome constrains such interactions is fundamental to our understanding of mammalian gene regulation. Here, we review recent progress in mapping long-range regulatory interactions in mammalian genomes, focusing on transcriptional enhancers and chromatin organization principles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation*
  • Genome*
  • Humans
  • Mammals / genetics*
  • Promoter Regions, Genetic
  • Transcription Factors / metabolism


  • Transcription Factors