Incidence of sexually transmitted infections in HIV-infected and HIV-uninfected adolescents in the USA

Int J STD AIDS. 2013 Feb;24(2):123-7. doi: 10.1177/0956462412472425. Epub 2013 May 6.


Little is known about the incidence of bacterial sexually transmitted infections (STIs) among HIV-infected versus HIV-uninfected adolescents. This secondary analysis of a national, multisite study included adolescents aged 12-18 years who were behaviourally HIV-infected (n = 346) or HIV-uninfected but at-risk (n = 182). Incidence rates of bacterial STIs (gonorrhoea, chlamydia [CT] and trichomonas [TV; women]) were calculated using Poisson modelling. Factors associated with incident STIs were explored using Cox proportional hazards modelling. HIV-infected versus HIV-uninfected women had higher TV incidence (1.3 versus 0.6/100 person-months; P = 0.002). HIV-uninfected versus HIV-infected women had higher CT incidence (1.6 versus 1.1/100 person-months; P = 0.04). Among women, demographic, behavioural and HIV-related factors were associated with incident STIs. Among men, there were no differences in incident STIs. In this first analysis comparing STI incidence between HIV-infected and HIV-uninfected adolescents, bacterial STI incidence among women significantly differed by HIV status, and factors associated with incident STIs varied by STI and HIV status.

Keywords: HIV; STI; adolescent; incidence; risk factors; sexually transmitted infection.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Child
  • Chlamydia Infections / complications
  • Chlamydia Infections / epidemiology*
  • Chlamydia Infections / microbiology
  • Female
  • Gonorrhea / complications
  • Gonorrhea / epidemiology*
  • Gonorrhea / microbiology
  • HIV Infections / complications*
  • HIV Infections / epidemiology
  • HIV Seronegativity*
  • Humans
  • Incidence
  • Interviews as Topic
  • Longitudinal Studies
  • Male
  • Multivariate Analysis
  • Proportional Hazards Models
  • Risk Factors
  • Socioeconomic Factors
  • Surveys and Questionnaires
  • Trichomonas Infections / complications
  • Trichomonas Infections / epidemiology*
  • Trichomonas Infections / microbiology
  • United States / epidemiology