Abstract
Chemical investigation of the aerial parts of Illicium simonsii resulted in the isolation of nine new compounds, simonsols A-E (1-5), simonsins A-B (7-8), terpene-sesquineolignans, clovanedunnianol (9), and p-menthadunnianol (10). Compound 5 was equilibrated with 7 as an inseparable mixture. The structures were elucidated by extensive NMR and MS analysis. Compounds 9, 10, and the mixture of 5 and 7 moderately inhibited acetylcholinesterase with IC50 values of 4.58 µM, 6.55 µM, and 10.34 µM, respectively.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Heterocyclic Compounds, 3-Ring / chemistry
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Heterocyclic Compounds, 3-Ring / isolation & purification*
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Heterocyclic Compounds, 4 or More Rings / isolation & purification*
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Humans
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Illicium / chemistry*
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Molecular Structure
Substances
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Benzofurans
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Cholinesterase Inhibitors
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Heterocyclic Compounds, 3-Ring
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Heterocyclic Compounds, 4 or More Rings