Hodgkin's disease in patients with antibodies to human immunodeficiency virus. A study of 22 patients

Cancer. 1990 May 15;65(10):2248-54. doi: 10.1002/1097-0142(19900515)65:10<2248::aid-cncr2820651015>3.0.co;2-w.


The experience of 22 Hodgkin's disease (HD) patients with human immunodeficiency virus type I (HIV) antibodies, collected from a cooperative study of six hospitals during 1984-1989 is presented. Young men (average age, 27.6 years) with a high incidence of intravenous drug abuse (86%) were found. The status of the HIV infection at diagnosis of HD was: four patients, acquired immune deficiency syndrome (AIDS); eight patients, persistent generalized lymphadenopathy (PGL); and ten patients, asymptomatic. The natural history of HD was unusual, with a high incidence of B symptoms (81%), advanced Stages III to IV (90%), bone marrow invasion (50%), cytopenias before treatment (45%), opportunistic infections (68%), and aggressive histologies. A decreased response to chemotherapy with poor marrow tolerance and a significant decrease in survival, 18 months, was observed. The AIDS and cytopenias pretreatment were associated with a shorter statistically significant survival, which defines the importance of immunodeficiency in HD prognosis. Complete remission after treatment was a factor that contributed to a longer statistically significant survival. The PGL or asymptomatic patients survived longer but also had a poor course, and five of them had AIDS criteria during evolution. A high incidence of HD in relation to non-Hodgkin's lymphoma (NHL) in patients with HIV infection in the six cooperating hospitals was found. Criteria for considering HD as an AIDS-associated lymphoproliferative disease in our environment are discussed.

MeSH terms

  • Acquired Immunodeficiency Syndrome / complications
  • Acquired Immunodeficiency Syndrome / mortality
  • Adult
  • Combined Modality Therapy
  • HIV Infections / complications*
  • HIV Infections / mortality
  • Hodgkin Disease / epidemiology*
  • Hodgkin Disease / mortality
  • Hodgkin Disease / pathology
  • Hodgkin Disease / therapy
  • Humans
  • Incidence
  • Lymphoma, Non-Hodgkin / complications
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Opportunistic Infections / epidemiology
  • Opportunistic Infections / mortality
  • Remission Induction
  • Survival Rate