Metaproteomics: harnessing the power of high performance mass spectrometry to identify the suite of proteins that control metabolic activities in microbial communities

Anal Chem. 2013 May 7;85(9):4203-14. doi: 10.1021/ac303053e. Epub 2013 Mar 21.


The availability of extensive genome information for many different microbes, including unculturable species in mixed communities from environmental samples, has enabled systems-biology interrogation by providing a means to access genomic, transcriptomic, and proteomic information. To this end, metaproteomics exploits the power of high-performance mass spectrometry for extensive characterization of the complete suite of proteins expressed by a microbial community in an environmental sample.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Bacterial Proteins / metabolism*
  • Mass Spectrometry*
  • Proteome / analysis*
  • Proteome / metabolism*
  • Proteomics*


  • Bacterial Proteins
  • Proteome