Abstract
Anti-oxidative, anti-tumor-promoting, and anti-carcinogenic activities of adonirubin and adonixanthin, which are biosynthetic intermediates from β-carotene to astaxanthin, were investigated. Both adonirubin and adonixanthin showed almost the same activities for inhibition of lipid peroxidation and quenching of singlet oxygen as those of astaxanthin. Furthermore, adonirubin and adonixanthin exhibited an inhibitory effect on Epstein-Barr virus early antigen activation in Raji cells and carcinogensis of mouse skin tumors initiated by 7,12-dimethylbenz[a]anthracene and promoted by 12-O-tetradecanoylphorbol-13-acetate.
MeSH terms
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9,10-Dimethyl-1,2-benzanthracene / antagonists & inhibitors
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Animals
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Anticarcinogenic Agents / chemistry
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Anticarcinogenic Agents / metabolism
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Anticarcinogenic Agents / pharmacology*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / metabolism
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Antineoplastic Agents / pharmacology*
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Antioxidants / chemistry
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Antioxidants / metabolism
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Antioxidants / pharmacology*
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Canthaxanthin / analogs & derivatives*
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Canthaxanthin / biosynthesis
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Canthaxanthin / chemistry
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Canthaxanthin / pharmacology
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Carotenoids / biosynthesis
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Carotenoids / chemistry
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Carotenoids / pharmacology*
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Cell Line, Tumor
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Female
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Humans
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Lipid Peroxidation / drug effects
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Mice
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Mice, Inbred ICR
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Molecular Structure
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Paracoccus / chemistry
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Paracoccus / metabolism
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Singlet Oxygen / chemistry
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Skin Neoplasms / chemically induced
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Skin Neoplasms / drug therapy*
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Structure-Activity Relationship
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Tetradecanoylphorbol Acetate / antagonists & inhibitors
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Viral Matrix Proteins / antagonists & inhibitors*
Substances
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Anticarcinogenic Agents
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Antineoplastic Agents
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Antioxidants
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EBV-associated membrane antigen, Epstein-Barr virus
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Viral Matrix Proteins
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Singlet Oxygen
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Carotenoids
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Canthaxanthin
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9,10-Dimethyl-1,2-benzanthracene
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adonirubin
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Tetradecanoylphorbol Acetate
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adonixanthin