Transient optic perineuritis as the initial presentation of central nervous system involvement by pre-B cell lymphocytic leukemia

J Neuroophthalmol. 2013 Jun;33(2):162-4. doi: 10.1097/WNO.0b013e318281b84d.


A 20-year-old man with a history of pre-B cell acute lymphocytic leukemia (ALL) presented with optic perineuritis of the right eye while undergoing chemotherapy. Evaluation failed to reveal an infectious or neoplastic cause, and the patient improved with oral corticosteroid treatment. He returned 10 weeks later with complete loss of vision in the right eye. Optic nerve biopsy revealed leukemic infiltration of the optic nerve, and the patient was treated for central nervous system (CNS) relapse of ALL. Transient optic perineuritis may be the initial manifestation of CNS involvement of pre-B cell ALL.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Cortex Hormones / therapeutic use
  • Central Nervous System / pathology*
  • Fluorescein Angiography
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Optic Neuritis / drug therapy
  • Optic Neuritis / physiopathology*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Vision Disorders / etiology
  • Vision Disorders / pathology
  • Young Adult


  • Adrenal Cortex Hormones