Epidemiological determinants of successful vaccine development

Int J Med Sci. 2013;10(4):382-4. doi: 10.7150/ijms.5689. Epub 2013 Feb 21.


Epidemiological determinants of successful vaccine development were explored using measurable biological variables including antigenic stability and requirement of T-cell immunity. Employing a logistic regression model, we demonstrate that a high affinity with blood and immune cells and pathogen interactions (e.g. interference) would be the risk factors of failure for vaccine development.

Keywords: Vaccination; epidemiology; immunization; infectious disease; statistical model..

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Communicable Disease Control
  • Communicable Diseases / epidemiology*
  • Communicable Diseases / therapy
  • Humans
  • Immunotherapy, Active*
  • Infant
  • Infant, Newborn
  • T-Lymphocytes / immunology
  • Vaccination*
  • Vaccines / immunology
  • Vaccines / therapeutic use*


  • Vaccines