Biomimetic treatment on dental implants for short-term bone regeneration

Clin Oral Investig. 2014 Jan;18(1):59-66. doi: 10.1007/s00784-013-0953-z. Epub 2013 Mar 8.


Objectives: The main purpose of this work was to assess the short-term bone regenerative potential of new osteoconductive implants. The novelty of the study lies in the analysis of the effectiveness of a novel two-step treatment which combines shot-blasting with a thermo-chemical treatment, at very short times after implant placement in a minipig model.

Materials and methods: Three hundred twenty implants with four different surface treatments, namely bioactivated surfaces, micro-rough grit-blasted, micro-rough acid-etched and smooth as-machined titanium implants were placed into the bone of 20 minipigs. The percent of bone-to-implant contact was determined 3 days, 1, 2, 3 and 10 weeks after implant placement by histomorphometric analysis. Surface composition, topography and wettability of the implant specimens were analysed.

Results: The combination of shot-blasting and thermo-chemical treatment accelerated bone regeneration at early stages in comparison with all other treatments between day 3 and week 3 (p < 0.05). The value of osseointegration attained at week 2 was maintained until the end of the experiment without any significant changes (percent direct contact ≈ 85 %). This was mostly attributed to the ability of these implants to form in vivo a layer of apatitic mineral that coated the implant and could rapidly stimulate bone nucleation and growth from the implant surface.

Conclusions: The surface quality resulting from this treatment on cpTi provided dental implants with a unique ability of rapid bone regeneration and osseointegration.

Clinical relevance: This treatment represents a step forward in the direction of reducing the time prior to implant loading.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomimetics
  • Bone Regeneration*
  • Coated Materials, Biocompatible / pharmacokinetics*
  • Coated Materials, Biocompatible / therapeutic use
  • Dental Etching / methods
  • Dental Implantation, Endosseous / adverse effects*
  • Immediate Dental Implant Loading
  • Models, Animal
  • Surface Properties
  • Swine
  • Swine, Miniature
  • Titanium / chemistry


  • Coated Materials, Biocompatible
  • Titanium