An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation

Adam J Bass; Timothy C Wang

doi:10.1016/j.stem.2013.02.004

An inflammatory situation: SOX2 and STAT3 cooperate in squamous cell carcinoma initiation

Cell Stem Cell. 2013 Mar 7;12(3):266-8. doi: 10.1016/j.stem.2013.02.004.

Authors

Adam J Bass¹, Timothy C Wang

Affiliation

¹ Division of Molecular and Cellular Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

PMID: 23472866
DOI: 10.1016/j.stem.2013.02.004

Abstract

Although SOX2 has been identified as a squamous cell carcinoma oncogene, mechanisms of SOX2-induce oncogenesis have remained elusive. In this issue of Cell Stem Cell, Li et al. (2013) show that SOX2 synergizes with inflammation-induced STAT3 activation to transform basal progenitors and initiate squamous cell carcinoma.

Publication types

Comment

Grants and funding

U54 CA163004/CA/NCI NIH HHS/United States