When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids

Gilbert Di Paolo; Serge Przedborski

doi:10.1016/j.neuron.2013.02.016

When Schwann cells conspire with mitochondria, neighboring axons are under attack by glia-derived neurotoxic lipids

Neuron. 2013 Mar 6;77(5):801-3. doi: 10.1016/j.neuron.2013.02.016.

Authors

Gilbert Di Paolo¹, Serge Przedborski

Affiliation

¹ Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

PMID: 23473310
DOI: 10.1016/j.neuron.2013.02.016

Abstract

In this issue of Neuron, Viader et al. (2013) report on the production of toxic lipids by Schwann cells deficient in mitochondrial respiration, which are capable of destroying neighboring axons. This may have implications for understanding the neurobiology and treatment of mitochondrial neuropathies.

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