Lamins A and C are not expressed at early stages of human lymphocyte differentiation

Exp Cell Res. 1990 Jul;189(1):145-7. doi: 10.1016/0014-4827(90)90267-e.


Lamins are major proteins of the nuclear envelope that are members of the intermediate filament protein family. In vertebrates, nuclei from differentiated tissues usually contain both lamins of the A and B subtypes, while embryonic tissues contain the B-type lamin only. We have examined the composition of the nuclear lamina in human B and T lymphocytes representative of distinct stages of lymphoid differentiation. We show here that, in both cell lineages, while lamin B is constitutively expressed at all stages of differentiation, A-type lamin expression is restricted to later developmental stages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / analysis*
  • B-Lymphocytes / cytology
  • Cell Differentiation
  • Cell Line
  • Cell Nucleus / analysis
  • Humans
  • Lamin Type B
  • Lamins
  • Nuclear Proteins / analysis*
  • Nuclear Proteins / genetics
  • RNA, Messenger / analysis
  • Rats
  • T-Lymphocytes / analysis*
  • T-Lymphocytes / cytology
  • Tumor Cells, Cultured


  • Lamin Type B
  • Lamins
  • Nuclear Proteins
  • RNA, Messenger