Fish oil-supplementation increases appetite in healthy adults. A randomized controlled cross-over trial

Appetite. 2013 Jul:66:62-6. doi: 10.1016/j.appet.2013.02.019. Epub 2013 Mar 6.


Marine n-3 fatty acids are hypothesized to have beneficial effects on obesity and cancer cachexia possibly via an effect on appetite. The aim of this study was to investigate, if fish oil-supplementation affects appetite in healthy individuals. In a randomized cross-over study, 20 normal-weight subjects (50% females) were given ten 0.5-mL capsules/day of fish oil or soybean oil for 3 weeks separated by 1-week wash-out. In the end of each period, appetite was assessed by 10-cm visual analog scales immediately before and after a standardized breakfast. Results were analyzed in accordance with the paired design considering oil sequence and gender. All subjects completed both periods with a compliance of 96% and oil sequence did not affect the results. There was no difference between the two supplements in any pre-breakfast appetite scores, but the post-prandial sensation of being full was 1.21 cm (0.20; 2.22) lower after the fish oil-period. Furthermore, there was a supplement × gender-interaction on "desire to eat more" due to a score increase of 1.09 cm (0.28; 1.90) in women only. These results suggest that marine n-3 fatty acid may increase appetite. This finding would be potentially beneficial for patients with compromised nutritional status.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Appetite / drug effects*
  • Cross-Over Studies
  • Denmark
  • Dietary Supplements*
  • Double-Blind Method
  • Fatty Acids, Omega-3 / administration & dosage
  • Fatty Acids, Omega-3 / pharmacology*
  • Female
  • Humans
  • Male
  • Postprandial Period
  • Reference Values
  • Satiety Response / drug effects*
  • Sex Distribution
  • Young Adult


  • Fatty Acids, Omega-3