A new look at T cell receptor signaling to nuclear factor-κB

Trends Immunol. 2013 Jun;34(6):269-81. doi: 10.1016/j.it.2013.02.002. Epub 2013 Mar 7.


Antigen stimulation of T cell receptor (TCR) signaling to nuclear factor (NF)-κB is required for T cell proliferation and differentiation of effector cells. The TCR-to-NF-κB pathway is generally viewed as a linear sequence of events in which TCR engagement triggers a cytoplasmic cascade of protein-protein interactions and post-translational modifications, ultimately culminating in the nuclear translocation of NF-κB. However, recent findings suggest a more complex picture in which distinct signalosomes, previously unrecognized proteins, and newly identified regulatory mechanisms play key roles in signal transmission. In this review, we evaluate recent data and suggest areas of future emphasis in the study of this important pathway.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Active Transport, Cell Nucleus
  • Animals
  • Cell Nucleus / metabolism*
  • Humans
  • Lymphocyte Activation
  • Multiprotein Complexes / immunology
  • Multiprotein Complexes / metabolism*
  • NF-kappa B / metabolism*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism*
  • Signal Transduction / immunology
  • T-Lymphocytes / immunology*


  • Multiprotein Complexes
  • NF-kappa B
  • Receptors, Antigen, T-Cell