Curcumin inhibits the metastasis of K1 papillary thyroid cancer cells via modulating E-cadherin and matrix metalloproteinase-9 expression

Biotechnol Lett. 2013 Jul;35(7):995-1000. doi: 10.1007/s10529-013-1173-y. Epub 2013 Mar 9.

Abstract

The anti-metastatic effect of curcumin on papillary thyroid cancer K1 cells and its underlying mechanisms were investigated. Curcumin at 12.5, 25 and 50 μM promoted mesenchymal-epithelial transition and decreased the migration rate of K1 cells by 24-87%. Its mechanism may involve the up-regulation of E-cadherin expression levels and down-regulation of the activity and expression of matrix metalloproteinase-9.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Cadherins / metabolism*
  • Cell Line, Tumor / drug effects
  • Cell Movement / drug effects*
  • Curcumin / pharmacology*
  • Humans
  • Matrix Metalloproteinase 9 / metabolism*

Substances

  • Antineoplastic Agents
  • Cadherins
  • Matrix Metalloproteinase 9
  • Curcumin