Cell cycle progression by the repression of primary cilia formation in proliferating cells

Cell Mol Life Sci. 2013 Oct;70(20):3893-905. doi: 10.1007/s00018-013-1302-8. Epub 2013 Mar 9.

Abstract

In most cell types, primary cilia protrude from the cell surface and act as major hubs for cell signaling, cell differentiation, and cell polarity. With the exception of some cells ciliated during cell proliferation, most cells begin to disassemble their primary cilia at cell cycle re-entry. Although the role of primary cilia disassembly on cell cycle progression is still under debate, recent data have emerged to support the idea that primary cilia exert influence on cell cycle progression. In this review, we emphasize a non-mitotic role of Aurora-A not only in the ciliary resorption at cell cycle re-entry but also in continuous suppression of cilia regeneration during cell proliferation. We also summarize recent new findings indicating that forced induction/suppression of primary cilia can affect cell cycle progression, in particular the transition from G0/G1 to S phase. In addition, we speculate how (de)ciliation affects cell cycle progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics
  • Adaptor Proteins, Signal Transducing / metabolism
  • Animals
  • Aurora Kinases
  • Cell Cycle*
  • Cell Proliferation*
  • Centrosome / metabolism
  • Cilia / metabolism*
  • Humans
  • Phosphoproteins / genetics
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Protein Stability
  • Protein Transport
  • Protein-Serine-Threonine Kinases / genetics
  • Protein-Serine-Threonine Kinases / metabolism*
  • Regeneration*
  • Signal Transduction

Substances

  • Adaptor Proteins, Signal Transducing
  • NEDD9 protein, human
  • Phosphoproteins
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases