International differences in treatment effect: do they really exist and why?

Eur Heart J. 2013 Jun;34(24):1846-52. doi: 10.1093/eurheartj/eht071. Epub 2013 Mar 7.


With the increasing globalization of clinical trials, the opportunity exists to explore potential geographic differences in treatment effect within any major trial. Such geographic differences may arise because of international differences in patient selection, medical practice, or evaluation of outcomes, and such international variations need better documentation in trial reports. Appropriate pre-defined statistical analyses, including statistical tests of interaction regarding geographic heterogeneity in treatment effect, are important. Geographic variations are a particularly tricky form of subgroup analysis: they lack statistical power, are at best hypothesis-generating and can generate more confusion than insight. Referring to key examples, e.g. the PLATO and MERIT-HF, we emphasize the need for caution in interpreting evidence of potential geographic inconsistencies in treatment effect. Although it is appropriate to explore any biological or practical reasons for apparent geographic anomalies in treatment effect, the play of chance is often the most plausible and wise interpretation.

Keywords: Geographic differences; Randomized clinical trials; Subgroup analysis.

MeSH terms

  • Data Collection
  • Geography, Medical
  • Humans
  • Internationality*
  • Patient Selection
  • Professional Practice
  • Randomized Controlled Trials as Topic / methods
  • Randomized Controlled Trials as Topic / standards*
  • Treatment Outcome