Spontaneous resolution of a giant pulmonary bulla: what is the role of bronchodilator and anti-inflammatory therapy?

Tenn Med. 2013 Jan;106(1):39-42.


Spontaneous resolution of giant pulmonary bullae occurs infrequently. The mechanisms responsible for the natural elimination of giant bullae are variable. We report a patient who experienced spontaneous total regression of his giant bulla following intensification of his inhaled bronchodilator and airway anti-inflammatory therapies. This occurrence suggests that smoking cessation and optimization of inhaled bronchodilator and anti-inflammatory therapies should be undertaken before referral for surgical bullectomy. These relatively simple measures may obviate the need for an invasive procedure.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use*
  • Blister / diagnosis*
  • Blister / drug therapy*
  • Bronchodilator Agents / therapeutic use*
  • Bronchoscopy
  • Diagnosis, Differential
  • Humans
  • Male
  • Middle Aged
  • Pulmonary Emphysema / diagnosis*
  • Pulmonary Emphysema / drug therapy*
  • Radiography, Thoracic
  • Remission, Spontaneous


  • Anti-Inflammatory Agents
  • Bronchodilator Agents