The molecular hug between the ER and the mitochondria

Curr Opin Cell Biol. 2013 Aug;25(4):443-8. doi: 10.1016/ Epub 2013 Mar 13.


A long-observed but often neglected property of cellular organelles is their ability to associate into junctions. Aspects of cell physiology appear more and more to depend upon these contact sites, as their central molecular components are being identified. Contact sites between the endoplasmic reticulum (ER) and the mitochondria are emerging as a prime example of such contacts. The physiological role of these contact sites, first thought to be limited to the facilitation of lipid and calcium exchange between the two organelles, is found to extend to unexpected aspects of mitochondria and ER functions.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism
  • Endoplasmic Reticulum / chemistry
  • Endoplasmic Reticulum / metabolism*
  • Lipid Metabolism
  • Mitochondria / metabolism*
  • Mitochondrial Membranes / metabolism
  • Protein Transport
  • Yeasts / cytology*
  • Yeasts / metabolism


  • Calcium