A powerful molecular synergy between mutant Nucleophosmin and Flt3-ITD drives acute myeloid leukemia in mice

Leukemia. 2013 Sep;27(9):1917-20. doi: 10.1038/leu.2013.77. Epub 2013 Mar 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics
  • Disease Models, Animal
  • Epistasis, Genetic*
  • Leukemia, Myeloid, Acute / genetics*
  • Leukemia, Myeloid, Acute / metabolism
  • Mice
  • Mice, Knockout
  • Mutation*
  • Nuclear Proteins / genetics*
  • Nuclear Proteins / metabolism
  • Tandem Repeat Sequences*
  • fms-Like Tyrosine Kinase 3 / genetics*
  • fms-Like Tyrosine Kinase 3 / metabolism

Substances

  • Nuclear Proteins
  • nucleophosmin
  • Flt3 protein, mouse
  • fms-Like Tyrosine Kinase 3