Interference of xenoestrogen o,p'-DDT on the action of endogenous estrogens at environmentally realistic concentrations

Bull Environ Contam Toxicol. 2013 May;90(5):591-5. doi: 10.1007/s00128-013-0976-9. Epub 2013 Mar 12.

Abstract

Estrogenic effects of individual chemicals and mixtures of 17β-estradiol (E2) and o,p'-DDT were examined using pS2 and PR gene expressions in MCF-7 cells. Interactions between E2 and o,p'-DDT were evaluated by a statistical method based on factorial design. At levels close to environmentally realistic concentrations, no significant interactions between E2 and o,p'-DDT were observed, suggesting that the xenoestrogen (o,p'-DDT) could act in an additive way with the endogenous estrogen (E2). These results demonstrated the utility of this statistical method in a mixture study, and highlight the potential interference and health risk of low-level xenoestrogens, such as o,p'-DDT.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DDT / toxicity*
  • Dose-Response Relationship, Drug
  • Endocrine Disruptors / toxicity
  • Environmental Pollutants / toxicity
  • Estradiol / toxicity
  • Estrogens, Non-Steroidal / toxicity*
  • Gene Expression / drug effects
  • Humans
  • MCF-7 Cells
  • Presenilin-2 / genetics
  • Presenilin-2 / metabolism
  • Receptors, Progesterone / genetics
  • Receptors, Progesterone / metabolism

Substances

  • Endocrine Disruptors
  • Environmental Pollutants
  • Estrogens, Non-Steroidal
  • PSEN2 protein, human
  • Presenilin-2
  • Receptors, Progesterone
  • Estradiol
  • DDT
  • o,p'-DDT