Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 30 (2), 472

IL-32 Expression Is an Independent Prognostic Marker for Gastric Cancer

Affiliations

IL-32 Expression Is an Independent Prognostic Marker for Gastric Cancer

Sumiya Ishigami et al. Med Oncol.

Abstract

A strong link between inflammation and gastrointestinal cancer has been demonstrated. Interleukin (IL)-32 is a recently described pro-inflammatory cytokine characterized by the induction of nuclear factor kappa B (NF-κB) activation. We investigated whether IL-32 expression has clinical significance in gastric cancer. A total of 182 gastric cancer patients who received curative gastrectomy were enrolled in our study. IL-32 expression was detected by immunohistochemistry, and the correlation between clinicopathological features and IL-32 expression was analyzed. Tumor depth and lymph node metastases developed more frequently in IL-32-positive gastric cancer patients than those who were negative for IL-32 expression (p < 0.01). Lymphatic- and venous invasion in the IL-32-positive group were more severe than in cancer cells lacking IL-32 expression (p < 0.05). Multivariate analysis demonstrated that IL-32 is one of the prognostic markers (p < 0.03) for gastric cancer, in addition to nodal involvement and tumor depth. IL-32 positivity significantly affected clinicopathological factors. Thus, IL-32 expression in gastric cancer may serve as a preferential metastatic condition that allows cells to escape host antitumor immunity. Pro-inflammatory cytokines induce immunosuppression in a paracrine manner, thereby facilitating the metastasis of tumor cells.

Similar articles

See all similar articles

Cited by 17 PubMed Central articles

See all "Cited by" articles

References

    1. Autoimmun Rev. 2007 Jan;6(3):131-7 - PubMed
    1. Semin Cancer Biol. 2006 Feb;16(1):38-52 - PubMed
    1. Immunity. 2005 Jan;22(1):131-42 - PubMed
    1. Cytokine. 2010 Feb;49(2):171-6 - PubMed
    1. J Microbiol Biotechnol. 2008 Sep;18(9):1606-12 - PubMed

Publication types

LinkOut - more resources

Feedback