Imaging mass spectrometry-based molecular histology differentiates microscopically identical and heterogeneous tumors

J Proteome Res. 2013 Apr 5;12(4):1847-55. doi: 10.1021/pr301190g. Epub 2013 Mar 25.


Many tumors display significant cellular heterogeneity as well as molecular heterogeneity. Sensitive biomarkers that differentiate between diagnostically challenging tumors must contend with this heterogeneity. Mass spectrometry-based molecular histology of a patient series of heterogeneous, microscopically identical bone tumors highlighted the tumor cell types that could be characterized by a single profile and led to the identification of specific peptides that differentiate between the tumors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bone Neoplasms / metabolism
  • Bone Neoplasms / pathology*
  • Chondrosarcoma / metabolism
  • Chondrosarcoma / pathology*
  • Humans
  • Molecular Imaging / methods
  • Molecular Sequence Data
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
  • Tandem Mass Spectrometry