Abstract
Six unprecedented bisindole alkaloids, trigolutesins A and B (1-2) with a unique polycyclic skeleton and trigolutes A-D (3-6) with another polycyclic skeleton, were isolated from the twigs of Trigonostemon lutescens. Their structures and relative configurations were elucidated by spectroscopic data and single-crystal X-ray diffraction crystallography. Trigolutesin A (1) showed weak AChE inhibitory activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Cholinesterase Inhibitors / chemistry
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Crystallography, X-Ray
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Euphorbiaceae / chemistry*
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification*
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Indole Alkaloids / pharmacology
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Molecular Conformation
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Molecular Structure
Substances
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Cholinesterase Inhibitors
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Indole Alkaloids
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trigolutesin A