Neonatal Herpes Simplex Virus Infections

Pediatr Clin North Am. 2013 Apr;60(2):351-65. doi: 10.1016/j.pcl.2012.12.005.

Abstract

Neonatal herpes simplex virus infections are uncommon, but because of the morbidity and mortality associated with the infection they are often considered in the differential diagnosis of ill neonates. The use of polymerase chain reaction for diagnosis of central nervous system infections and the development of safe and effective antiviral therapy has revolutionized the diagnosis and management of these infants. Initiation of long-term antiviral suppressive therapy in these infants has led to significant improvement in morbidity. This article summarizes the epidemiology of neonatal herpes simplex virus infections and discusses clinical presentation, diagnosis, management, and follow up of infants with neonatal herpes disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acyclovir / administration & dosage
  • Acyclovir / therapeutic use*
  • Adult
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • Central Nervous System Viral Diseases / diagnosis
  • Central Nervous System Viral Diseases / virology
  • Developmental Disabilities / virology*
  • Diagnosis, Differential
  • Evidence-Based Medicine
  • Female
  • Herpes Genitalis / epidemiology
  • Herpes Simplex Virus Vaccines / administration & dosage
  • Herpes Simplex* / diagnosis
  • Herpes Simplex* / drug therapy
  • Herpes Simplex* / mortality
  • Herpes Simplex* / prevention & control
  • Humans
  • Infant, Newborn
  • Morbidity
  • Mothers
  • Polymerase Chain Reaction
  • Practice Guidelines as Topic
  • Pregnancy
  • Pregnancy Complications, Infectious* / diagnosis
  • Pregnancy Complications, Infectious* / drug therapy
  • Pregnancy Complications, Infectious* / epidemiology
  • Pregnancy Complications, Infectious* / mortality
  • Pregnancy Complications, Infectious* / prevention & control
  • Prognosis
  • Recurrence
  • Risk Factors
  • Severity of Illness Index
  • Simplexvirus / drug effects
  • Simplexvirus / genetics
  • Simplexvirus / immunology
  • Simplexvirus / isolation & purification*

Substances

  • Antiviral Agents
  • Herpes Simplex Virus Vaccines
  • Acyclovir

Supplementary concepts

  • Neonatal herpes