Hypoxia-driven immunosuppression contributes to the pre-metastatic niche

Oncoimmunology. 2013 Jan 1;2(1):e22355. doi: 10.4161/onci.22355.


Primary tumor cells create favorable microenvironments in secondary organs, termed pre-metastatic niches, that promote the formation of metastases. Using immune competent syngenic breast cancer mouse models, we have recently demonstrated that factors secreted by hypoxic tumor cells condition pre-metastatic niches by recruiting CD11b+/Ly6Cmed/Ly6G+ myeloid cells and suppressing natural killer cell functions.

Keywords: MDSC; NK cells; bone marrow-derived cells; breast cancer; hypoxia; immunosuppression; pre-metastatic niche.