T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Alexander Pedroza-Gonzalez; Jaap Kwekkeboom; Dave Sprengers

doi:10.4161/onci.22450

T-cell suppression mediated by regulatory T cells infiltrating hepatic tumors can be overcome by GITRL treatment

Oncoimmunology. 2013 Jan 1;2(1):e22450. doi: 10.4161/onci.22450.

Authors

Alexander Pedroza-Gonzalez¹, Jaap Kwekkeboom, Dave Sprengers

Affiliation

¹ Department of Gastroenterology and Hepatology; Erasmus MC-University Medical Center; Rotterdam, The Netherlands.

Abstract

Recently, we reported the accumulation of CD4⁺FOXP3⁺ regulatory T cells (Tregs) within the tumor mass of patients bearing liver cancer. Tumor-infiltrating Tregs (TiTregs) are active and potent suppressors of antitumor immunity. Importantly, treatment with GITRL reduced the immunosuppression mediated by TiTregs.

Keywords: GITRL; T cells; colorectal cancer; hepatocellular carcinoma; immunotherapy; liver cancer; liver metastasis; regulatory T cells.