Transcription factor Sox11 is essential for both embryonic and adult neurogenesis

Dev Dyn. 2013 Jun;242(6):638-53. doi: 10.1002/dvdy.23962. Epub 2013 Apr 28.


Background: Neurogenesis requires neural progenitor cell (NPC) proliferation, neuronal migration, and differentiation. During embryonic development, neurons are generated in specific areas of the developing neuroepithelium and migrate to their appropriate positions. In the adult brain, neurogenesis continues in the subgranular zone (SGZ) of the hippocampal dentate gyrus and the subventricular zone (SVZ) of the lateral ventricle. Although neurogenesis is fundamental to brain development and function, our understanding of the molecular mechanisms that regulate neurogenesis is still limited.

Results: In this study, we generated a Sox11 floxed allele and a Sox11 null allele in mice using the Cre-loxP technology. We first analyzed the role of the transcription factor Sox11 in embryonic neurogenesis using Sox11 null embryos. We also examined the role of Sox11 in adult hippocampal neurogenesis using Sox11 conditional knockout mice in which Sox11 is specifically deleted in adult NPCs. Sox11 null embryos developed small and disorganized brains, accompanied by transient proliferation deficits in NPCs. Deletion of Sox11 in adult NPCs blunted proliferation in the SGZ. Using functional genomics, we identified potential downstream target genes of Sox11.

Conclusions: Taken together, our work provides evidence that Sox11 is required for both embryonic and adult neurogenesis, and identifies potential downstream target genes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Alleles
  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Cell Death
  • Cell Differentiation
  • Cell Movement
  • Cell Proliferation
  • Crosses, Genetic
  • Dentate Gyrus / metabolism
  • Female
  • Gene Expression Regulation, Developmental
  • Genomics
  • Hippocampus / metabolism
  • Homeodomain Proteins / metabolism
  • Integrases / metabolism
  • Male
  • Mice
  • Mice, Knockout
  • Nerve Tissue Proteins / metabolism
  • Nervous System / embryology
  • Neurogenesis*
  • Neurons / metabolism*
  • SOXC Transcription Factors / metabolism
  • SOXC Transcription Factors / physiology*
  • Time Factors
  • Tumor Suppressor Proteins / metabolism


  • Basic Helix-Loop-Helix Transcription Factors
  • Homeodomain Proteins
  • Nerve Tissue Proteins
  • SOXC Transcription Factors
  • Sox11 protein, mouse
  • Tumor Suppressor Proteins
  • prospero-related homeobox 1 protein
  • Neurogenic differentiation factor 1
  • Cre recombinase
  • Integrases