Clinical significance of IgG anti-Sm antibodies in patients with systemic lupus erythematosus

J Rheumatol. 1990 Apr;17(4):469-75.


Free Sm was purified by gel filtration and anti-Sm affinity chromatography. Using this purified antigen, an ELISA for anti-Sm was performed. Three hundred and fifty patients with various rheumatic diseases were studied with respect to immunoglobulin classes of anti-Sm by ELISA. A high frequency of IgG anti-Sm was specifically detected in patients with systemic lupus erythematosus (SLE), but IgA and IgM anti-Sm showed a low frequency and also was detected in other diseases. In patients with SLE, anti-Sm significantly correlated with lung fibrosis and pericarditis. In our longitudinal study, there were increases in titer of IgG anti-Sm preceding central nervous system exacerbation and serositis. IgG anti-Sm was found to be not only a diagnostic marker but also a reliable measure of disease activity in SLE.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Antinuclear / analysis*
  • Antibody Specificity
  • Autoantigens / immunology*
  • Autoantigens / isolation & purification
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Immunoglobulin G / immunology*
  • Lupus Erythematosus, Systemic / immunology*
  • Lupus Erythematosus, Systemic / physiopathology
  • Male
  • Middle Aged
  • Ribonucleoproteins / immunology
  • Ribonucleoproteins, Small Nuclear*
  • snRNP Core Proteins


  • Antibodies, Antinuclear
  • Autoantigens
  • Immunoglobulin G
  • Ribonucleoproteins
  • Ribonucleoproteins, Small Nuclear
  • snRNP Core Proteins