Patent foramen ovale and migraine: what is the relationship between the two?

J Cardiol. 2013 Apr;61(4):256-9. doi: 10.1016/j.jjcc.2012.12.005. Epub 2013 Feb 26.


There is conflicting evidence on the causal relationship of patent foramen ovale (PFO) in migraine. This review will examine the pathophysiological relevance of PFO in migraine, the epidemiological evidence of PFO causing migraine, and the existing evidence on the effectiveness of closure of PFO on the symptomatology of migraine. From the current available evidence, the role of PFO in migraine is debatable, and interventions such as closure of PFO cannot yet be considered routine treatment of migraine.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic
  • Foramen Ovale, Patent / complications*
  • Foramen Ovale, Patent / physiopathology
  • Foramen Ovale, Patent / surgery
  • Humans
  • Migraine Disorders / etiology*
  • Migraine Disorders / therapy