Morphological changes of bladder mucosa in patients who underwent instillation with combined sodium hyaluronic acid-chondroitin sulphate (Ialuril®)

Urol Int. 2013;91(1):81-8. doi: 10.1159/000345047. Epub 2013 Mar 13.


Objective: To investigate what changes are endoscopically evident after glycosaminoglycans (GAGs) therapy by hyaluronic acid (HA) and chondroitin sulphate (CS) (Ialuril®) in female patients affected by bladder pain syndrome(BPS)/ interstitial cystitis (IC) or recurrent urinary tract infections (rUTIs).

Patients and methods: 21 female patients over 18 years affected by rUTIs or BPS/IC received intravesical instillation of HA and CS (4 weekly instillations followed by 2 instillations every 2 weeks and 2 instillation monthly). Post-treatment evaluation included cystoscopy and patient assessment of improvement in symptoms and satisfaction on a visual analogue scale (VAS) from 0 to 10.

Results: The post-treatment endoscopy showed a positive effect on bladder mucosa morphology. In 2 cases, treatment did not change endoscopic findings and clinical symptoms. In the other patients, when macroscopic features of the bladder mucosa normalized, the clinical picture improved.

Conclusions: GAGs therapy by HA and CS (Ialuril) improves the morphology of bladder mucosa in patients with rUTI or BPS/IC.

MeSH terms

  • Adult
  • Aged
  • Chondroitin Sulfates / administration & dosage*
  • Chondroitin Sulfates / therapeutic use
  • Cystitis / drug therapy
  • Cystitis, Interstitial / drug therapy*
  • Cystoscopy
  • Drug Combinations
  • Endoscopy / methods
  • Female
  • Glycosaminoglycans / therapeutic use
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / therapeutic use
  • Middle Aged
  • Mucous Membrane / pathology*
  • Urinary Bladder / pathology*
  • Urinary Bladder Diseases / drug therapy
  • Urinary Tract Infections / drug therapy*
  • Urothelium / metabolism
  • Urothelium / pathology


  • Drug Combinations
  • Glycosaminoglycans
  • chondroitin sulfate, sodium hyaluronate drug combination
  • Hyaluronic Acid
  • Chondroitin Sulfates