The ATM protein kinase: regulating the cellular response to genotoxic stress, and more

Nat Rev Mol Cell Biol. 2013 Apr;14(4):197-210. doi: 10.1038/nrm3546. Epub 2013 Mar 13.

Abstract

The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following induction of DSBs, ATM mobilizes one of the most extensive signalling networks that responds to specific stimuli and modifies directly or indirectly a broad range of targets. Although most ATM research has focused on this function, evidence suggests that ATM-mediated phosphorylation has a role in the response to other types of genotoxic stress. Moreover, it has become apparent that ATM is active in other cell signalling pathways involved in maintaining cellular homeostasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Ataxia Telangiectasia Mutated Proteins
  • Cell Cycle Proteins / metabolism*
  • DNA Damage
  • DNA Repair
  • DNA-Binding Proteins / metabolism*
  • Homeostasis / genetics
  • Humans
  • Models, Genetic
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction / genetics
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Cell Cycle Proteins
  • DNA-Binding Proteins
  • Tumor Suppressor Proteins
  • ATM protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Protein-Serine-Threonine Kinases