Combination Therapy With Naltrexone and Bupropion for Obesity Reduces Total and Visceral Adiposity

Diabetes Obes Metab. 2013 Sep;15(9):863-6. doi: 10.1111/dom.12095. Epub 2013 Apr 5.

Abstract

The effects of combination naltrexone/bupropion therapy on body composition and visceral adipose tissue (VAT) mass were examined in a subset (n = 107) of obese subjects from a Phase 2 trial that compared the efficacy and safety of placebo, naltrexone monotherapy, bupropion monotherapy or one of three naltrexone/bupropion dose combinations for 24 weeks. Body composition data were obtained using dual-energy X-ray absorptiometry and computed tomography. Eighty subjects completed the substudy. Naltrexone/bupropion resulted in weight loss and a greater reduction in body fat (-14.0 ± 1.3%) than placebo (-4.0 ± 2.0%), naltrexone monotherapy (-3.2 ± 2.5%) and bupropion monotherapy (-4.1 ± 2.9%; all p < 0.01). Reduction in VAT mass was also greater with naltrexone/bupropion (-15.0 ± 1.8%) than placebo (-4.6 ± 2.7%), naltrexone monotherapy (-0.1 ± 3.5%) and bupropion monotherapy (-2.3 ± 4.2%; all p < 0.01). Reductions in body fat and VAT mass with naltrexone/bupropion were proportional with weight loss. Weight loss with naltrexone/bupropion was not associated with a greater relative reduction in lean mass than placebo or the monotherapies.

Keywords: adipose tissue; antiobesity drug; body composition; clinical trial; obesity therapy; weight loss therapy.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorptiometry, Photon
  • Adiposity / drug effects*
  • Analysis of Variance
  • Body Composition / drug effects*
  • Bupropion / administration & dosage
  • Bupropion / therapeutic use*
  • Dopamine Uptake Inhibitors / administration & dosage
  • Dopamine Uptake Inhibitors / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Intra-Abdominal Fat / drug effects*
  • Male
  • Middle Aged
  • Naltrexone / administration & dosage
  • Naltrexone / therapeutic use*
  • Obesity / drug therapy*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Weight Loss / drug effects

Substances

  • Dopamine Uptake Inhibitors
  • Bupropion
  • Naltrexone