Study of mature cells in human myeloid malignancies by premature chromosome condensation

Nouv Rev Fr Hematol. 1990;32(1):117-9.


The premature chromosome condensation technique allows cytogenetic studies (chromosomes scoring or karyotyping after banding) of mature non cycling cells. In conjunction with cell fractionation, it appears a powerful tool to study spontaneous or therapy-induced maturation of cells of acute myelogenous leukemia or myelodysplastic syndrome patients. It is useful for determining the involvement of multiple lineages in hematopoietic diseases.

MeSH terms

  • Chromosomes*
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute / genetics*
  • Myelodysplastic Syndromes / genetics*