Curcuminoids modulate pro-oxidant-antioxidant balance but not the immune response to heat shock protein 27 and oxidized LDL in obese individuals

Phytother Res. 2013 Dec;27(12):1883-8. doi: 10.1002/ptr.4952. Epub 2013 Mar 15.


Curcuminoids have potentially important functional qualities including anti-inflammatory and antioxidant properties. In this randomized double-blind placebo-controlled cross-over trial, the effects of a curcuminoid supplement on serum pro-oxidant-antioxidant balance (PAB) and antibody titres to Hsp27 (anti-Hsp27) and oxLDL (anti-oxLDL) were investigated. Thirty obese individuals were randomized to receive either curcuminoids (1 g/day) or placebo for a period of 30 days. After a wash-out period of 2 weeks, subjects were crossed over to the alternate regimen for another 30 days. Serum PAB along with anti-Hsp27 and anti-oxLDL titres was measured at the beginning and at the end of each study period. There was no significant carry-over effect for any of the assessed parameters. Curcuminoid supplementation was associated with a significant decrease in PAB (p = 0.044). However, no significant change was observed in serum concentrations of anti-Hsp27 or anti-oxLDL (p > 0.05). These findings suggest that oral curcuminoids supplementation (1g/day) is effective in reducing oxidative stress burden, though this needs to be validated in larger study populations.

Keywords: curcumin; heat shock protein 27; oxidative stress; oxidized low-density lipoprotein.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antibodies / blood
  • Antioxidants / metabolism*
  • Cross-Over Studies
  • Curcumin / pharmacology*
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • HSP27 Heat-Shock Proteins / immunology*
  • Heat-Shock Proteins
  • Humans
  • Lipoproteins, LDL / immunology*
  • Male
  • Middle Aged
  • Molecular Chaperones
  • Obesity / immunology*
  • Oxidants / blood*
  • Oxidative Stress / drug effects
  • Reactive Oxygen Species / metabolism
  • Reactive Oxygen Species / pharmacology


  • Antibodies
  • Antioxidants
  • HSP27 Heat-Shock Proteins
  • HSPB1 protein, human
  • Heat-Shock Proteins
  • Lipoproteins, LDL
  • Molecular Chaperones
  • Oxidants
  • Reactive Oxygen Species
  • oxidized low density lipoprotein
  • Curcumin