Vinculin, cell mechanics and tumour cell invasion

Cell Biol Int. 2013 May;37(5):397-405. doi: 10.1002/cbin.10064. Epub 2013 Mar 13.


The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actins / metabolism
  • Animals
  • Apoptosis
  • Carcinogenesis
  • Cell Adhesion
  • Cell Movement
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction
  • Vinculin / chemistry
  • Vinculin / metabolism*


  • Actins
  • Vinculin