Raphanus sativus L. var niger as a source of phytochemicals for the prevention of cholesterol gallstones

Phytother Res. 2014 Feb;28(2):167-71. doi: 10.1002/ptr.4964. Epub 2013 Mar 15.


Raphanus sativus L. var niger (black radish) is a plant of the cruciferous family with important ethnobotanical uses for the treatment of gallstones in Mexican traditional medicine. It has been established that the juice of black radish decreases cholesterol levels in plasma and dissolves gallstones in mice. Glucosinolates, the main secondary metabolites of black radish, can hydrolyze into its respective isothiocyanates and have already demonstrated antioxidant properties as well as their ability to diminish hepatic cholesterol levels; such therapeutic effects can prevent the formation of cholesterol gallstones. This disease is considered a current problem of public health. In the present review, we analyze and discuss the therapeutic effects of the main glucosinolates of black radish, as well as the effects that this plant has on cholesterol gallstones disease.

Keywords: Raphanus sativus L. var niger; cholesterol; gallstones; glucosinolates.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticholesteremic Agents / pharmacology*
  • Antioxidants / pharmacology
  • Cholesterol / chemistry*
  • Gallstones / drug therapy
  • Gallstones / prevention & control*
  • Glucosinolates / pharmacology
  • Humans
  • Imidoesters / pharmacology
  • Isothiocyanates / pharmacology
  • Liver / drug effects
  • Medicine, Traditional
  • Mice
  • Oximes
  • Phytochemicals / chemistry*
  • Plant Extracts / pharmacology
  • Raphanus / chemistry*
  • Sulfoxides


  • 4-methylthio-3-butenyl glucosinolate
  • Anticholesteremic Agents
  • Antioxidants
  • Glucosinolates
  • Imidoesters
  • Isothiocyanates
  • Oximes
  • Phytochemicals
  • Plant Extracts
  • Sulfoxides
  • isothiocyanic acid
  • Cholesterol
  • glucoraphanin