PEG hydrogel degradation and the role of the surrounding tissue environment

J Tissue Eng Regen Med. 2015 Mar;9(3):315-8. doi: 10.1002/term.1688. Epub 2013 Mar 12.


Poly(ethylene glycol) (PEG)-based hydrogels are extensively used in a variety of biomedical applications, due to ease of synthesis and tissue-like properties. Recently there have been varied reports regarding PEG hydrogel's degradation kinetics and in vivo host response. In particular, these studies suggest that the surrounding tissue environment could play a critical role in defining the inflammatory response and degradation kinetics of PEG implants. In the present study we demonstrated a potential mechanism of PEG hydrogel degradation, and in addition we show potential evidence of the role of the surrounding tissue environment on producing variable inflammatory responses.

Keywords: degradation; hydrogel; inflammatory response; macrophages; neutrophils; poly(ethylene glycol); reactive oxygen species (ROS).

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Hydrogels / pharmacokinetics*
  • Hydrogels / pharmacology
  • Materials Testing*
  • Organ Specificity / drug effects
  • Polyethylene Glycols / pharmacokinetics*
  • Polyethylene Glycols / pharmacology
  • Rats
  • Rats, Sprague-Dawley


  • Hydrogels
  • Polyethylene Glycols
  • polyethylene glycol 1000