Perioperative music may reduce pain and fatigue in patients undergoing laparoscopic cholecystectomy

Acta Anaesthesiol Scand. 2013 Sep;57(8):1010-6. doi: 10.1111/aas.12100. Epub 2013 Mar 18.

Abstract

Background: Acute post-operative pain is a predictor in the development of chronic pain after laparoscopic cholecystectomy. Music has been shown to reduce surgical stress. In a randomized, clinical trial, we wanted to test the hypothesis that perioperative and post-operative soft music reduces pain, nausea, fatigue and surgical stress in patients undergoing laparoscopic cholecystectomy as day surgery.

Method: The study was performed in otherwise healthy Danish patients eligible for day surgery. Ninety-three patients were included and randomized to either soft music or no music perioperatively and post-operatively. Using visual analog score pain, nausea and fatigue at baseline, 1 h, 3 h, 1 day and 7 days after surgery were recorded. C-reactive protein and cortisol were sampled before and after surgery.

Results: Music did not lower pain 3 h after surgery, which was the main outcome. The music group had less pain day 7 (P = 0.014). Nausea was low in both groups and was not affected by music. The music group experienced less fatigue at day 1 (P = 0.042) and day 7 (P = 0.015). Cortisol levels decreased during surgery in the music group (428.5-348.0 nmol/l), while it increased in the non-music group (443.5-512.0 nmol/l); still, the difference between the two groups were only significant using general linear models as post-hoc analysis. Soft music did not affect C-reactive protein levels.

Conclusion: Soft music did not reduce pain 3 h after laparoscopic cholecystectomy. Soft music may reduce later post-operative pain and fatigue by decreasing the surgical stress response.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Anesthesia
  • C-Reactive Protein / analysis
  • Cholecystectomy, Laparoscopic*
  • Early Ambulation
  • Fatigue / prevention & control*
  • Female
  • Humans
  • Hydrocortisone / blood
  • Male
  • Middle Aged
  • Music / psychology*
  • Pain Measurement
  • Pain, Postoperative / prevention & control*
  • Perioperative Care / psychology*
  • Postoperative Complications / prevention & control*
  • Postoperative Nausea and Vomiting / epidemiology
  • Postoperative Nausea and Vomiting / prevention & control
  • Sample Size
  • Stress, Physiological / physiology
  • Treatment Outcome

Substances

  • C-Reactive Protein
  • Hydrocortisone