Dynamic integration of splicing within gene regulatory pathways

Cell. 2013 Mar 14;152(6):1252-69. doi: 10.1016/j.cell.2013.02.034.


Precursor mRNA splicing is one of the most highly regulated processes in metazoan species. In addition to generating vast repertoires of RNAs and proteins, splicing has a profound impact on other gene regulatory layers, including mRNA transcription, turnover, transport, and translation. Conversely, factors regulating chromatin and transcription complexes impact the splicing process. This extensive crosstalk between gene regulatory layers takes advantage of dynamic spatial, physical, and temporal organizational properties of the cell nucleus, and further emphasizes the importance of developing a multidimensional understanding of splicing control.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Cell Nucleus / genetics
  • Chromatin / metabolism
  • Gene Regulatory Networks*
  • Humans
  • RNA Splicing*
  • Regulatory Sequences, Ribonucleic Acid
  • Transcription, Genetic


  • Chromatin
  • Regulatory Sequences, Ribonucleic Acid