Chromatin remodeling at DNA double-strand breaks

Cell. 2013 Mar 14;152(6):1344-54. doi: 10.1016/j.cell.2013.02.011.


DNA double-strand breaks (DSBs) can arise from multiple sources, including exposure to ionizing radiation. The repair of DSBs involves both posttranslational modification of nucleosomes and concentration of DNA-repair proteins at the site of damage. Consequently, nucleosome packing and chromatin architecture surrounding the DSB may limit the ability of the DNA-damage response to access and repair the break. Here, we review early chromatin-based events that promote the formation of open, relaxed chromatin structures at DSBs and that allow the DNA-repair machinery to access the spatially confined region surrounding the DSB, thereby facilitating mammalian DSB repair.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly*
  • DNA Breaks, Double-Stranded*
  • DNA Repair*
  • Genomic Instability
  • Histones / metabolism
  • Humans
  • Neoplasms / genetics


  • Histones