Allosteric controls of nuclear receptor function in the regulation of transcription

J Mol Biol. 2013 Jul 10;425(13):2317-29. doi: 10.1016/j.jmb.2013.03.017. Epub 2013 Mar 15.


Nuclear receptors control a large number of physiological events through the regulation of gene transcription. Their activation function involves and is controlled by ligands and multiple cofactors (repressors, activators and bridging proteins). Further post-translational modifications resulting from the crosstalk between different signaling pathways provide additional regulations. The numerous players involved allow the sophisticated fine-tuning of transcriptional regulation. The present review describes how allosteric mechanisms are used in the control of the sequential and ordered binding of nuclear receptors and the various protein effectors to target DNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Allosteric Regulation*
  • Crystallography, X-Ray
  • Gene Expression Regulation*
  • Models, Biological
  • Models, Molecular
  • Molecular Dynamics Simulation
  • Protein Conformation
  • Receptors, Cytoplasmic and Nuclear / chemistry*
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Signal Transduction
  • Transcription, Genetic*


  • Receptors, Cytoplasmic and Nuclear