Angiopoietin signaling in the vasculature

Exp Cell Res. 2013 May 15;319(9):1271-80. doi: 10.1016/j.yexcr.2013.03.011. Epub 2013 Mar 13.


The angiopoietin (Ang) growth factors and the endothelial Tie receptors regulate blood and lymphatic vessel development, and vascular permeability, inflammation, angiogenic remodeling and tumor vascularization in adult tissues. The angiopoietins activate the Tie receptors in unique in trans complexes at endothelial cell-cell and cell-matrix contacts. In addition, integrins have been implicated in the regulation of Ang-Tie signaling. Recent interest has focused on the function of angiopoietin-2 and its inhibition in the tumor vasculature and also in other pathological conditions associated with endothelial dysfunction. Here we review the current understanding of the signaling functions of the Ang-Tie pathway and its potential for future development of targeted vascular therapeutics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiopoietins / physiology*
  • Animals
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / pathology
  • Cardiovascular System / growth & development
  • Cardiovascular System / metabolism
  • Cardiovascular System / pathology
  • Endothelium, Vascular / metabolism
  • Extracellular Matrix / metabolism
  • Humans
  • Lymphatic System / growth & development
  • Neovascularization, Physiologic
  • Permeability
  • Signal Transduction*


  • Angiopoietins