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. 2013 Apr;24(4):562-8.
doi: 10.1177/0956797612457952. Epub 2013 Mar 15.

Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities

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Free PMC article

Common DNA Markers Can Account for More Than Half of the Genetic Influence on Cognitive Abilities

Robert Plomin et al. Psychol Sci. .
Free PMC article

Abstract

For nearly a century, twin and adoption studies have yielded substantial estimates of heritability for cognitive abilities, although it has proved difficult for genomewide-association studies to identify the genetic variants that account for this heritability (i.e., the missing-heritability problem). However, a new approach, genomewide complex-trait analysis (GCTA), forgoes the identification of individual variants to estimate the total heritability captured by common DNA markers on genotyping arrays. In the same sample of 3,154 pairs of 12-year-old twins, we directly compared twin-study heritability estimates for cognitive abilities (language, verbal, nonverbal, and general) with GCTA estimates captured by 1.7 million DNA markers. We found that DNA markers tagged by the array accounted for .66 of the estimated heritability, reaffirming that cognitive abilities are heritable. Larger sample sizes alone will be sufficient to identify many of the genetic variants that influence cognitive abilities.

Conflict of interest statement

Declaration of Conflicting Interests: The authors declared that they had no conflicts of interest with respect to their authorship or the publication of this article.

Figures

Fig. 1.
Fig. 1.
Distribution of chance genetic similarity across 1.7 million single-nucleotide polymorphisms for 3,154 unrelated individuals, pair by pair. The sample was taken from the Twins Early Development Study sample.

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