Genetic algorithms and MCML program for recovery of optical properties of homogeneous turbid media

Biomed Opt Express. 2013 Mar 1;4(3):433-46. doi: 10.1364/BOE.4.000433. Epub 2013 Feb 15.

Abstract

In this paper, we present and validate a new method for optical properties recovery of turbid media with slab geometry. This method is an iterative method that compares diffuse reflectance and transmittance, measured using integrating spheres, with those obtained using the known algorithm MCML. The search procedure is based in the evolution of a population due to selection of the best individual, i.e., using a genetic algorithm. This new method includes several corrections such as non-linear effects in integrating spheres measurements and loss of light due to the finite size of the sample. As a potential application and proof-of-principle experiment of this new method, we use this new algorithm in the recovery of optical properties of blood samples at different degrees of coagulation.

Keywords: (170.3660) Light propagation in tissues; (170.5280) Photon migration; (290.7050) Turbid media.