Abstract
Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acids / chemistry
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Coordination Complexes / chemistry
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Coordination Complexes / pharmacology*
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Guanine / analogs & derivatives
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Guanine / chemistry
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Humans
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Naphthoquinones / chemistry
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Naphthoquinones / pharmacology*
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Osmium / chemistry
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Osmium / pharmacology*
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Reactive Oxygen Species / metabolism
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Rhodium / chemistry
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Rhodium / pharmacology*
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Ruthenium / chemistry
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Ruthenium / pharmacology*
Substances
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Amino Acids
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Antineoplastic Agents, Phytogenic
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Coordination Complexes
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Naphthoquinones
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Reactive Oxygen Species
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Osmium
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Guanine
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Ruthenium
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9-ethylguanine
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lapachol
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Rhodium