Organometallic anticancer complexes of lapachol: metal centre-dependent formation of reactive oxygen species and correlation with cytotoxicity

Chem Commun (Camb). 2013 Apr 25;49(32):3348-50. doi: 10.1039/c3cc40432c.

Abstract

Organometallic Ru(II), Os(II) and Rh(III) complexes of lapachol induce apoptosis in human tumour cell lines in the low μM range by a mode of action involving oxidative stress, especially in the case of the ruthenium compound.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acids / chemistry
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Coordination Complexes / chemistry
  • Coordination Complexes / pharmacology*
  • Guanine / analogs & derivatives
  • Guanine / chemistry
  • Humans
  • Naphthoquinones / chemistry
  • Naphthoquinones / pharmacology*
  • Osmium / chemistry
  • Osmium / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Rhodium / chemistry
  • Rhodium / pharmacology*
  • Ruthenium / chemistry
  • Ruthenium / pharmacology*

Substances

  • Amino Acids
  • Antineoplastic Agents, Phytogenic
  • Coordination Complexes
  • Naphthoquinones
  • Reactive Oxygen Species
  • Osmium
  • Guanine
  • Ruthenium
  • 9-ethylguanine
  • lapachol
  • Rhodium