Electrophysiological characteristics of cholinergic and non-cholinergic neurons in the rat medial septum-diagonal band complex

Brain Res. 1990 Apr 9;513(1):171-4. doi: 10.1016/0006-8993(90)91106-q.


We examined the electrophysiological properties of cholinergic and non-cholinergic neurons in the medial septum-diagonal band complex (MSDB) of the rat in the in vitro slice preparation. Cells were identified electrophysiologically, filled with Lucifer yellow, fixed and processed for immunohistochemistry with fluorescent labeled anti-choline acetyltransferase (ChAT) antibody. Cholinergic and non-cholinergic neurons differed in action potential parameters, spike afterpotentials and in current-voltage relationships. In addition, cholinergic neurons expressed a potent transient outward rectification in response to a depolarizing current pulse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials
  • Animals
  • Choline O-Acetyltransferase / metabolism
  • Cholinergic Fibers / enzymology
  • Cholinergic Fibers / physiology*
  • Frontal Lobe / physiology*
  • Immunohistochemistry
  • In Vitro Techniques
  • Rats
  • Septal Nuclei / physiology*


  • Choline O-Acetyltransferase